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Article

Expression profiling of murine double-negative regulatory T cells suggest mechanisms for prolonged cardiac allograft survival.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2005

Lee Boris P-L, Mansfield Elaine, Hsieh Szu-Chuan, Hernandez-Boussard Tina, Chen Wenhao, Thomson Christopher W, Ford Megan S, Bosinger Steven E, Der Sandy, Zhang Zhu-Xu, Zhang Meixia, Kelvin David J, Sarwal Minnie M, Zhang Li

Abstract excerpt

Recent studies have demonstrated that both mouse and human alpha beta TCR(+)CD3(+)NK1.1(-)CD4(-)CD8- double-negative regulatory T (DN Treg) cells can suppress Ag-specific immune responses mediated by CD8+ and CD4+ T cells. To identify molecules involved in DN Treg cell function, we generated a panel of murine DN Treg clones, which specifically kill activated syngeneic CD8+ T cells. Through serial cultivation of...

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Identifiers

PMID: 15814674
DOI: 10.4049/jimmunol.174.8.4535

Genes

CXCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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