Article
Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease.
PloS one - 1 Jan 2016
Ward-Caviness Cavin K, Neas Lucas M, Blach Colette, Haynes Carol S, LaRocque-Abramson Karen, Grass Elizabeth, Dowdy Elaine, Devlin Robert B, Diaz-Sanchez David, Cascio Wayne E, Lynn Miranda Marie, Gregory Simon G, Shah Svati H, Kraus William E, Hauser Elizabeth R
Abstract excerpt
There is a growing literature indicating that genetic variants modify many of the associations between environmental exposures and clinical outcomes, potentially by increasing susceptibility to these exposures. However, genome-scale investigations of these interactions have been rarely performed particularly in the case of air pollution exposures. We performed race-stratified genome-wide gene-environment...
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