Article
Polymorphisms in DNA repair genes, traffic-related polycyclic aromatic hydrocarbon exposure and breast cancer incidence.
International journal of cancer - 15 Jul 2016
Mordukhovich Irina, Beyea Jan, Herring Amy H, Hatch Maureen, Stellman Steven D, Teitelbaum Susan L, Richardson David B, Millikan Robert C, Engel Lawrence S, Shantakumar Sumitra, Steck Susan E, Neugut Alfred I, Rossner Pavel, Santella Regina M, Gammon Marilie D
Abstract excerpt
Vehicular traffic polycyclic aromatic hydrocarbons (PAHs) have been associated with breast cancer incidence in epidemiologic studies, including our own. Because PAHs damage DNA by forming adducts and oxidative lesions, genetic polymorphisms that alter DNA repair capacity may modify associations between PAH-related exposures and breast cancer risk. Our goal was to examine the association between vehicular traffic...
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