Article
Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease.
Environmental health perspectives - 1 Aug 2008
Melén Erik, Nyberg Fredrik, Lindgren Cecilia M, Berglind Niklas, Zucchelli Marco, Nordling Emma, Hallberg Jenny, Svartengren Magnus, Morgenstern Ralf, Kere Juha, Bellander Tom, Wickman Magnus, Pershagen Göran
Abstract excerpt
BACKGROUND: Air pollutants may induce airway inflammation and sensitization due to generation of reactive oxygen species. The genetic background to these mechanisms could be important effect modifiers. OBJECTIVE: Our goal was to assess interactions between exposure to air pollution and single nucleotide polymorphisms (SNPs) in the beta2-adrenergic receptor (ADRB2), glutathione S-transferase P1 (GSTP1), and tumor...
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