Article
Editor's Highlight: Modifying Role of Endothelial Function Gene Variants on the Association of Long-Term PM2.5 Exposure With Blood DNA Methylation Age: The VA Normative Aging Study.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Jul 2017
Nwanaji-Enwerem Jamaji C, Bind Marie-Abele, Dai Lingzhen, Oulhote Youssef, Colicino Elena, Di Qian, Just Allan C, Hou Lifang, Vokonas Pantel, Coull Brent A, Weisskopf Marc G, Baccarelli Andrea A, Schwartz Joel D
Abstract excerpt
Recent studies have reported robust associations of long-term PM2.5 exposure with DNA methylation-based measures of aging; yet, the molecular implications of these relationships remain poorly understood. We evaluated if genetic variation in 3 biological pathways implicated in PM2.5-related disease-oxidative stress, endothelial function, and metal processing-could modify the effect of PM2.5 on DNAm-age, one...
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