Article
Interaction effects of long-term air pollution exposure and variants in the GSTP1, GSTT1 and GSTCD genes on risk of acute myocardial infarction and hypertension: a case-control study.
PloS one - 1 Jan 2014
Levinsson Anna, Olin Anna-Carin, Modig Lars, Dahgam Santosh, Björck Lena, Rosengren Annika, Nyberg Fredrik
Abstract excerpt
INTRODUCTION: Experimental and epidemiological studies have reported associations between air pollution exposure, in particular related to vehicle exhaust, and cardiovascular disease. A potential pathophysiological pathway is pollution-induced pulmonary oxidative stress, with secondary systemic inflammation. Genetic polymorphisms in genes implicated in oxidative stress, such as GSTP1, GSTT1 and GSTCD, may...
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