Article
Experimental and molecular dynamics studies showed that CBP KIX mutation affects the stability of CBP:c-Myb complex.
Computational biology and chemistry - 1 Jun 2016
Odoux Anne, Jindal Darren, Tamas Tamara C, Lim Benjamin W H, Pollard Drake, Xu Wu
Abstract excerpt
The coactivators CBP (CREBBP) and its paralog p300 (EP300), two conserved multi-domain proteins in eukaryotic organisms, regulate gene expression in part by binding DNA-binding transcription factors. It was previously reported that the CBP/p300 KIX domain mutant (Y650A, A654Q, and Y658A) altered both c-Myb-dependent gene activation and repression, and that mice with these three point mutations had reduced numbers...
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