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Article

Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms.

The EMBO journal - 20 Jun 2007

Xu Wu, Kasper Lawryn H, Lerach Stephanie, Jeevan Trushar, Brindle Paul K

Abstract excerpt

CREB is a key mediator of cAMP- and calcium-inducible transcription, where phosphorylation of serine 133 in its Kinase-Inducible Domain (KID) is often equated with transactivation. Phospho-Ser133 is required for CREB to bind the KIX domain of the coactivators CBP and p300 (CBP/p300) in vitro, alt...

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Identifiers

PMID: 17525731
DOI: 10.1038/sj.emboj.7601734
PMCID: PMC1894772

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17525731-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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