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Article

Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment.

Proceedings of the National Academy of Sciences of the United States of America - 17 Apr 2012

Wang Feng, Marshall Christopher B, Yamamoto Kazuo, Li Guang-Yao, Gasmi-Seabrook Geneviève M C, Okada Hitoshi, Mak Tak W, Ikura Mitsuhiko

Abstract excerpt

Forkhead box class O 3a (FOXO3a) is a transcription factor and tumor suppressor linked to longevity that determines cell fate through activating transcription of cell differentiation, survival, and apoptotic genes. Recruitment of the coactivator CBP/p300 is a crucial step in transcription, and we revealed that in addition to conserved region 3 (CR3) of FOXO3a, the C-terminal segment of CR2 (CR2C) binds CBP/p300...

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Identifiers

PMID: 22474372
DOI: 10.1073/pnas.1119073109
PMCID: PMC3341034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment.PMID 22474372Read ↗

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