Article
Tertiary structure prediction of the KIX domain of CBP using Monte Carlo simulations driven by restraints derived from multiple sequence alignments.
Proteins - 15 Feb 1998
Ortiz A R, Kolinski A, Skolnick J
Abstract excerpt
Using a recently developed protein folding algorithm, a prediction of the tertiary structure of the KIX domain of the CREB binding protein is described. The method incorporates predicted secondary and tertiary restraints derived from multiple sequence alignments in a reduced protein model whose c...
Topics
- Algorithms
- Amino Acid Sequence
- CREB-Binding Protein
- Databases as Topic
- Models, Molecular
- Molecular Sequence Data
- Monte Carlo Method
- Mutation
- Nuclear Proteins
- Protein Folding
- Protein Structure, Secondary
- Protein Structure, Tertiary
- Sequence Alignment
- Trans-Activators
- Transcription Factors