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Article

The Parkinson Disease gene SNCA: Evolutionary and structural insights with pathological implication.

Scientific reports - 15 Apr 2016

Siddiqui Irum Javaid, Pervaiz Nashaiman, Abbasi Amir Ali

Abstract excerpt

After Alzheimer, Parkinson's disease (PD) is the second most common neurodegenerative disorder. Alpha synuclein (SNCA) is deemed as a major component of Lewy bodies, a neuropathological feature of PD. Five point mutations in SNCA have been reported so far, responsible for autosomal dominant PD. This study aims to decipher evolutionary and structural insights of SNCA by revealing its sequence and structural...

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Source

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Identifiers

PMID: 27080380
DOI: 10.1038/srep24475
PMCID: PMC4832246

Genes

SNCA
SNCB
SNCG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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