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Article

In silico analysis of alpha-synuclein protein variants and posttranslational modifications related to Parkinson's disease.

Journal of cellular biochemistry - 1 Mar 2024

da Silva Aloma N R, Pereira Gabriel R C, Bonet Luiz Felippe Sarmento, Outeiro Tiago Fleming, De Mesquita Joelma F

Abstract excerpt

Parkinson's disease (PD) is among the most prevalent neurodegenerative disorders, affecting over 10 million people worldwide. The protein encoded by the SNCA gene, alpha-synuclein (ASYN), is the major component of Lewy body (LB) aggregates, a histopathological hallmark of PD. Mutations and posttranslational modifications (PTMs) in ASYN are known to influence protein aggregation and LB formation, possibly playing...

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Identifiers

PMID: 38239037
DOI: 10.1002/jcb.30523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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