Genetics of α-Synuclein: The Prime Pathological Player of Parkinson's Disease.

Abstract excerpt

Parkinson's disease is a complex neurodegenerative disorder that results from the interplay of genetic, environmental, and age-associated factors. The characteristic pathological feature of the disease is the presence of aggregated forms of the intrinsically disordered protein α-synuclein. Protein aggregates eventually form Lewy bodies, which are associated with the death of dopaminergic neurons. Elevated...

Topics

• alpha-Synuclein
• Humans
• Animals
• Parkinson Disease
• Mutation