Article
Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2016
Crescente Marilena, Pluthero Fred G, Li Ling, Lo Richard W, Walsh Tony G, Schenk Michael P, Holbrook Lisa M, Louriero Silvia, Ali Marfoua S, Vaiyapuri Sakthivel, Falet Hervé, Jones Ian M, Poole Alastair W, Kahr Walter H A, Gibbins Jonathan M
Abstract excerpt
OBJECTIVE: Thiol isomerases facilitate protein folding in the endoplasmic reticulum, and several of these enzymes, including protein disulfide isomerase and ERp57, are mobilized to the surface of activated platelets, where they influence platelet aggregation, blood coagulation, and thrombus formation. In this study, we examined the synthesis and trafficking of thiol isomerases in megakaryocytes, determined their...
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