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Article

Unfolded Protein Response Differentially Modulates the Platelet Phenotype.

Circulation research - 5 Aug 2022

Jain Kanika, Tyagi Tarun, Du Jing, Hu Xiaoyue, Patell Kanchi, Martin Kathleen A, Hwa John

Abstract excerpt

BACKGROUND: Unfolded protein response (UPR) is a multifaceted signaling cascade that alleviates protein misfolding. Although well studied in nucleated cells, UPR in absence of transcriptional regulation has not been described. Intricately associated with cardiovascular diseases, platelets, despite being anucleate, respond rapidly to stressors in blood. We investigate the UPR in anucleate platelets and explore its...

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Identifiers

PMID: 35862006
DOI: 10.1161/CIRCRESAHA.121.320530
PMCID: PMC9357223

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