Genetic and genomic insights into the molecular basis of atherosclerosis.

doi:10.1016/j.cmet.2007.07.001

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Article

Genetic and genomic insights into the molecular basis of atherosclerosis.

Cell metabolism - 1 Sept 2007

Chen Yaoyu, Rollins Jarod, Paigen Beverly, Wang Xiaosong

Abstract excerpt

Atherosclerosis is a complex disease involving genetic and environmental risk factors, acting on their own or in synergy. Within the general population, polymorphisms within genes in lipid metabolism, inflammation, and thrombogenesis are probably responsible for the wide range of susceptibility to myocardial infarction, a fatal consequence of atherosclerosis. Genetic linkage studies have been carried out in both...

Topics

Animals
Atherosclerosis
Chromosome Mapping
Enzyme Inhibitors
Genetic Linkage
Genetic Predisposition to Disease
Humans
Quantitative Trait Loci
Risk Factors

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Identifiers

PMID: 17767904
DOI: 10.1016/j.cmet.2007.07.001
PMCID: PMC2083632

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