Article
Experimental Biology for the Identification of Causal Pathways in Atherosclerosis.
Cardiovascular drugs and therapy - 1 Feb 2016
Guo Yanhong, Garcia-Barrio Minerva T, Wang Laiyuan, Chen Y Eugene
Abstract excerpt
More than 60 genomic loci have been implicated by genome-wide association studies (GWAS) and exome-wide association studies as conferring an increased risk of myocardial infarction and coronary artery disease (CAD). However, the causal gene and variant is often unclear. Using the functional analysis of genetic variants in experimental animal models, we anticipate understanding which candidate gene at a specific...
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