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Article

Systems Approach to Integrating Preclinical Apolipoprotein E-Knockout Investigations Reveals Novel Etiologic Pathways and Master Atherosclerosis Network in Humans.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2022

Shuey Megan M, Xiang Rachel R, Moss M Elizabeth, Carvajal Brigett V, Wang Yihua, Camarda Nicholas, Fabbri Daniel, Rahman Protiva, Ramsey Jacob, Stepanian Alec, Sebastiani Paola, Wells Quinn S, Beckman Joshua A, Jaffe Iris Z

Abstract excerpt

OBJECTIVE: Animal models of atherosclerosis are used extensively to interrogate molecular mechanisms in serial fashion. We tested whether a novel systems biology approach to integration of preclinical data identifies novel pathways and regulators in human disease. Approach and Results: Of 716 articles published in ATVB from 1995 to 2019 using the apolipoprotein E knockout mouse to study atherosclerosis, data were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Knockout, ApoE

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Source

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Identifiers

PMID: 34758633
DOI: 10.1161/ATVBAHA.121.317071
PMCID: PMC8887835

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