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Article

RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation

25 Apr 2015

Abstract excerpt

The activity of antagonizing transcription factors represents a mechanistic paradigm of bidirectional lineage-fate control during hematopoiesis. At the megakaryocytic/erythroid bifurcation, the cross-antagonism of krueppel-like factor 1 (KLF1) and friend leukemia integration 1 (FLI1) has such a decisive role. However, how this antagonism is resolved during lineage specification is poorly understood. We found that...

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PMID: 25911237
DOI: 10.1182/blood-2014-11-610519

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