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Article

Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver.

The Journal of biological chemistry - 3 Jun 2016

Zhao Ningning, Maxson Julia E, Zhang Richard H, Wahedi Mastura, Enns Caroline A, Zhang An-Sheng

Abstract excerpt

Hemojuvelin (HJV) regulates iron homeostasis by direct interaction with bone morphogenetic protein (BMP) ligands to induce hepcidin expression through the BMP signaling pathway in the liver. Crystallography studies indicate that HJV can simultaneously bind to both BMP2 and the ubiquitously expressed cell surface receptor neogenin. However, the role of the neogenin-HJV interaction in the function of HJV is...

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Source

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Identifiers

PMID: 27072365
DOI: 10.1074/jbc.M116.721191
PMCID: PMC4933279

Genes

HJV
BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

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Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver.PMID 27072365Read ↗

Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane.Semantic proximity Read ↗

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.Semantic proximity Read ↗

Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression.Semantic proximity Read ↗

Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that hemojuvelin is dispensable for sensing body iron levels.Semantic proximity Read ↗

Bone morphogenetic proteins as regulators of iron metabolism.Semantic proximity Read ↗

Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsivenessSemantic proximity Read ↗

Endofin, a novel BMP-SMAD regulator of the iron-regulatory hormone, hepcidin.Semantic proximity Read ↗

Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin.Semantic proximity Read ↗

Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6.Semantic proximity Read ↗

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overloadSemantic proximity Read ↗

Potential Roles of BMP9 in Liver FibrosisSemantic proximity Read ↗

Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression.Semantic proximity Read ↗

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