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Article

Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2006

Truksa Jaroslav, Peng Hongfan, Lee Pauline, Beutler Ernest

Abstract excerpt

Recently, it has been suggested that hepcidin, a peptide involved in iron homeostasis, is regulated by bone morphogenetic proteins (BMPs), apparently by binding to hemojuvelin (Hjv) as a coreceptor and signaling through Smad4. We investigate the role of Hfe, Tfr2 (transferrin receptor 2), and IL-6 in BMP2-, BMP4-, and BMP9-stimulated up-regulation of murine hepcidin, because these molecules, like Hjv, are known...

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Identifiers

PMID: 16801541
DOI: 10.1073/pnas.0603124103
PMCID: PMC1502450

Genes

BMP2
BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6.PMID 16801541Read ↗

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BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism.Semantic proximity Read ↗

Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsivenessSemantic proximity Read ↗

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.Semantic proximity Read ↗

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