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Article

Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that hemojuvelin is dispensable for sensing body iron levels.

PloS one - 1 Jan 2014

Gkouvatsos Konstantinos, Fillebeen Carine, Daba Alina, Wagner John, Sebastiani Giada, Pantopoulos Kostas

Abstract excerpt

Hemojuvelin (Hjv) is a bone morphogenetic protein (BMP) co-receptor involved in the control of systemic iron homeostasis. Functional inactivation of Hjv leads to severe iron overload in humans and mice due to marked suppression of the iron-regulatory hormone hepcidin. To investigate the role of Hjv in body iron sensing, Hjv-/- mice and isogenic wild type controls were placed on a moderately low, a standard or a...

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PMID: 24409331
DOI: 10.1371/journal.pone.0085530
PMCID: PMC3883712

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