Article
Contribution of DNA Repair Xeroderma Pigmentosum Group D Genotypes to Colorectal Cancer Risk in Taiwan.
Anticancer research - 1 Apr 2016
Chang Wen-Shin, Yueh Te-Cheng, Tsai Chia-Wen, Ji Hong-Xue, Wu Cheng-Nan, Wang Shou-Cheng, Lai Yi-Liang, Hsu Shih-Wei, Hsieh Ming-Hao, Hsiao Chieh-Lun, Hung Yi-Wen, Shih Tzu-Ching, Bau Da-Tian
Abstract excerpt
BACKGROUND/AIM: It has been previously proposed that genetic variations on DNA repair genes confer susceptibility to cancer and the DNA repair gene Xeroderma Pigmentosum Group D (XPD) is thought to play the role of a helicase during excision repair and transcription. We investigated three genotypes of XPD, at promoter -114 (rs3810366), Asp312Asn (rs1799793) and Lys751Gln (rs13181), regarding their association...
Read the complete abstract on PubMed