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Article

Association of adenylyl cyclase 6 rs3730070 polymorphism and hemolytic level in patients with sickle cell anemia.

Blood cells, molecules & diseases - 1 May 2016

Cita Kizzy-Clara, Ferdinand Séverine, Connes Philippe, Brudey Laura, Tressières Benoit, Etienne-Julan Maryse, Lemonne Nathalie, Tarer Vanessa, Elion Jacques, Romana Marc

Abstract excerpt

A recent study suggested that adenosine signaling pathway could promote hemolysis in patients with sickle cell anemia (SCA). This signaling pathway involves several gene coding enzymes for which variants have been described. In this study, we analyzed the genotype-phenotype relationships between functional polymorphisms or polymorphisms associated with altered expression of adenosine pathway genes, namely...

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PMID: 27067484
DOI: 10.1016/j.bcmd.2016.02.006

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