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Article

beta(2)-Adrenergic receptor and adenylate cyclase gene polymorphisms affect sickle red cell adhesion.

British journal of haematology - 1 Apr 2008

Eyler Christine E, Jackson Terry, Elliott Laine E, De Castro Laura M, Jonassaint Jude, Ashley-Koch Allison, Telen Marilyn J

Abstract excerpt

Sickle red cell (SS RBC) adhesion is thought to contribute to sickle cell disease (SCD) pathophysiology. SS RBC adhesion to laminin increases in response to adrenaline stimulation of beta(2)-adrenergic receptors (beta(2)ARs) and adenylate cyclase (ADCY6), and previous evidence suggests such activ...

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Topics

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Share to Adenylyl Cyclases
Share to Anemia, Sickle Cell
Share to Cell Adhesion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Erythrocytes

Share to Genotype

Share to Laminin

Share to Polymorphism, Single Nucleotide

Share to Receptors, Adrenergic, beta-2

Source

Identifiers

PMID: 18324973
DOI: 10.1111/j.1365-2141.2008.07008.x

Genes

ADCY6
ADRB2
SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18324973-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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