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Article

Novel Mutations L228I and Y232H Cause Nonnucleoside Reverse Transcriptase Inhibitor Resistance in Combinational Pattern.

AIDS research and human retroviruses - 1 Sept 2016

Zhang Xiao-Min, Zhang Qiwei, Wu Hao, Lau Terrence Chi-Kong, Liu Xuan, Chu Hin, Zhang Ke, Zhou Jie, Chen Zhi-Wei, Jin Dong-Yan, Zheng Bo-Jian

Abstract excerpt

The emergence of drug resistance mutations is increasing after the implementation of highly active antiretroviral therapy. To characterize two novel mutations L228I and Y232H in the primer grip of reverse transcriptase (RT) of HIV-1 circulating recombination form 08_BC (CRF08_BC) subtype, both mutant clones were constructed to determine their impacts on viral phenotypic susceptibility and replication capacity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27067022
DOI: 10.1089/AID.2015.0359
PMCID: PMC5028909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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