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Article

Identification of the critical sites of NNRTI-resistance in reverse transcriptase of HIV-1 CRF_BC strains.

PloS one - 1 Jan 2014

Huang Yang, Li Zhenpeng, Xing Hui, Jiao Yang, Ouyang Yabo, Liao Lingjie, Jiang Shibo, Armstrong Rebecca, Shao Yiming, Ma Liying

Abstract excerpt

BACKGROUND: The polymorphisms involved in drug resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) in HIV-1 CRF_BC, the most prevalent HIV-1 strain in China, have been poorly characterized. RESULTS: To reveal the drug resistance mutations, we compared the gene sequences of pol region of HIV-1 CRF_BC from 631 treatment-naïve and 363 treatment-experienced patients using the selection...

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Topics

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Share to Drug Resistance, Viral
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Reverse Transcriptase

Share to pol Gene Products, Human Immunodeficiency Virus

Share to Polymorphism, Genetic

Share to Reverse Transcriptase Inhibitors

Share to Selection, Genetic

Source

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Identifiers

PMID: 24743727
DOI: 10.1371/journal.pone.0093804
PMCID: PMC3990534

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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