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Article

[Replication kinetic properties of HIV-1 CRF_BC novel drug resistance associated mutations].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] - 1 May 2015

Jiao Yang, Huang Yang, Li Shuming, Li Zhenpeng, Wang Yan, Yin Qianqian, Ma Liying

Abstract excerpt

OBJECTIVE: To study the drug sensitivity and analyze the replication kinetics of HIV-1 B and CRF07_BC subtypes with I132L or T139K/R mutations. METHODS: The amino acids in position 132 and 139 of reverse transcriptase (RT) region of the infectious clone PNL4-3 (HIV-1 B subtype) were changed to L and T/R through site mutagenesis. Combined with the previously constructed infectious clone of HIV-1 CRF07_BC subtype...

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PMID: 26081708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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