Article
Distinct resistance patterns to etravirine and rilpivirine in viruses containing nonnucleoside reverse transcriptase inhibitor mutations at baseline.
AIDS (London, England) - 27 Mar 2013
Asahchop Eugene L, Wainberg Mark A, Oliveira Maureen, Xu Hongtao, Brenner Bluma G, Moisi Daniela, Ibanescu Ilinca R, Tremblay Cecile
Abstract excerpt
OBJECTIVE: The current in-vitro study examined HIV-1 drug resistance patterns following etravirine (ETR) and rilpivirine (RPV) drug pressure in viruses containing baseline nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance mutations. DESIGN AND METHOD: Several baseline mutations were introduced into NL-4.3 (subtype B clone) by site-directed mutagenesis. This virus, together with two subtype C...
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