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Targeting MAPAKAP2(MK2) to combat inflammation by avoiding the differential regulation of anti-inflammatory genes by p38 MAPK inhibitors

2022-07-18

Abstract excerpt

<h4>ABSTRACT</h4> p38 mitogen-activated protein kinase (p38 MAPK) plays an important role in the key cellular processes related to inflammation. Several small molecule inhibitors of p38 MAPK therefore have been evaluated for their anti-inflammatory potential and progressed from early discovery to late phase clinical trials. Most of these efforts however have failed due to severe toxicity concerns. Since p38 MAPK...

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Literature Corpus work
5a6f1d0d-3624-56d8-a8f0-99338c534c7e
DOI
10.1101/2022.07.17.500377
Open publication

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