Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of PLCbeta2 by endotoxin plays a role in the adenosine A(2A) receptor-mediated switch of macrophages from an inflammatory to an angiogenic phenotype.

The American journal of pathology - 1 Dec 2009

Grinberg Stan, Hasko Gyorgy, Wu Dianqing, Leibovich Samuel Joseph

Abstract excerpt

Toll-like receptor (TLR) 2, 4, 7, and 9 agonists, together with adenosine A(2A) receptor (A(2A)R) agonists, switch macrophages from an inflammatory (M1) to an angiogenic (M2-like) phenotype. This switch involves induction of A(2A)Rs by TLR agonists, down-regulation of tumor necrosis factor alpha...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunoprecipitation
Share to Lipopolysaccharides
Share to Macrophage Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myeloid Differentiation Factor 88

Share to Neovascularization, Physiologic

Share to Phospholipase C beta

Share to Receptor, Adenosine A2A

Share to Vascular Endothelial Growth Factor A

Source

Open in PubMed Open full text

Identifiers

PMID: 19850892
DOI: 10.2353/ajpath.2009.090290
PMCID: PMC2789640

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19850892-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of PLCbeta2 by endotoxin plays a role in the adenosine A(2A) receptor-mediated switch of macrophages from an inflammatory to an angiogenic phenotype.PMID 19850892Read ↗

Adenosine A2A receptor signaling attenuates LPS-induced pro-inflammatory cytokine formation of mouse macrophages by inducing the expression of DUSP1.Semantic proximity Read ↗

Adenosine receptor activation promotes macrophage class switching from LPS-induced acute inflammatory M1 to anti-inflammatory M2 phenotype.Semantic proximity Read ↗

Proteinase-activated receptor 2 activation promotes an anti-inflammatory and alternatively activated phenotype in LPS-stimulated murine macrophages.Semantic proximity Read ↗

Purinergic signaling during macrophage differentiation results in M2 alternative activated macrophages.Semantic proximity Read ↗

Expression of G alpha i2 mimics several aspects of LPS priming in a murine macrophage-like cell line.Semantic proximity Read ↗

Phospholipase C δ1 in macrophages negatively regulates TLR4-induced proinflammatory cytokine production and Fcγ receptor-mediated phagocytosis.Semantic proximity Read ↗

New insights into the regulation of inflammation by adenosine.Semantic proximity Read ↗

Lipopolysaccharide-induced activation of beta2-integrin function in macrophages requires Irak kinase activity, p38 mitogen- activated protein kinase, and the Rap1 GTPase.Semantic proximity Read ↗

Induction of M2 regulatory macrophages through the β2-adrenergic receptor with protection during endotoxemia and acute lung injury.Semantic proximity Read ↗

ILK mediates LPS-induced vascular adhesion receptor expression and subsequent leucocyte trans-endothelial migration.Semantic proximity Read ↗

TLR4 and TNFR1 blockade dampen M1 macrophage activation and shifts them towards an M2 phenotype.Semantic proximity Read ↗

Regulation of macrophage IL-10 production postinjury via beta2 integrin signaling and the P38 MAP kinase pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.