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Article

p53 family members in cancer diagnosis and treatment.

Seminars in cancer biology - 1 Feb 2010

Machado-Silva Alice, Perrier Stéphane, Bourdon Jean-Christophe

Abstract excerpt

p53 is a much studied transcription factor which has a key role in the maintenance of genetic stability. It belongs to a larger family of genes including two other highly related proteins, p63 and p73. The p53 pathway has a vital role in the prevention of cancer formation and is ubiquitously lost in a high percentage of human cancers. In 60% of cancer cases this occurs via p53 gene mutation. In the remaining...

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Identifiers

PMID: 20206267
DOI: 10.1016/j.semcancer.2010.02.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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