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Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae

18 Jan 2018

Abstract excerpt

Leprosy is a chronic human disease caused by the yet-uncultured pathogen Mycobacterium leprae. Although readily curable with multidrug therapy (MDT), over 200,000 new cases are still reported annually. Here, we obtain M. leprae genome sequences from DNA extracted directly from patients' skin biopsies using a customized protocol. Comparative and phylogenetic analysis of 154 genomes from 25 countries provides...

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PMID: 29367657
DOI: 10.1038/s41467-017-02576-z

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