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Article

miR-29b and miR-198 overexpression in CD8+ T cells of renal cell carcinoma patients down-modulates JAK3 and MCL-1 leading to immune dysfunction.

Journal of translational medicine - 11 Apr 2016

Gigante Margherita, Pontrelli Paola, Herr Wolfgang, Gigante Maddalena, D'Avenia Morena, Zaza Gianluigi, Cavalcanti Elisabetta, Accetturo Matteo, Lucarelli Giuseppe, Carrieri Giuseppe, Battaglia Michele, Storkus Walter J, Gesualdo Loreto, Ranieri Elena

Abstract excerpt

BACKGROUND: Mammalian microRNAs (miR) regulate the expression of genes relevant for the development of adaptive and innate immunity against cancer. Since T cell dysfunction has previously been reported in patients with renal cell carcinoma (RCC; clear cell type), we aimed to analyze these immune cells for genetic and protein differences when compared to normal donor T cells freshly after isolation and 35 days...

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Share to Carcinoma, Renal Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27063186
DOI: 10.1186/s12967-016-0841-9
PMCID: PMC4827202

Genes

JAK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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