Article

Determinants of anti-PD1 response and resistance in clear cell renal cell carcinoma

2021-03-24

Abstract excerpt

<h4>Summary</h4> Antigen recognition and T-cell mediated cytotoxicity in clear-cell renal cell carcinoma (ccRCC) remains incompletely understood. To address this knowledge gap, we analysed 115 multiregion tumour samples collected from 15 treatment-naïve patients pre- and post-nivolumab therapy, and at autopsy in three patients. We performed whole-exome sequencing, RNAseq, TCRseq, multiplex immunofluorescence and f...

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Literature Corpus work: 19a030ab-9459-53c1-a9f8-d1e1f204371d
DOI: 10.1101/2021.03.19.21253661

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