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Noncoding RNA s and immune checkpoints—clinical implications as cancer therapeutics

29 Jan 2017

Abstract excerpt

A major mechanism of tumor development and progression is silencing of the patient's immune response to cancer-specific antigens. Defects in the so-called cancer immunity cycle may occur at any stage of tumor development. Within the tumor microenvironment, aberrant expression of immune checkpoint molecules with activating or inhibitory effects on T lymphocytes induces immune tolerance and cellular immune escape....

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PMID: 28132417
DOI: 10.1111/febs.14030

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