Article
PD-1 expression on peripheral blood cells increases with stage in renal cell carcinoma patients and is rapidly reduced after surgical tumor resection.
Cancer immunology research - 1 Apr 2014
MacFarlane Alexander W, Jillab Mowafaq, Plimack Elizabeth R, Hudes Gary R, Uzzo Robert G, Litwin Samuel, Dulaimi Essel, Al-Saleem Tahseen, Campbell Kerry S
Abstract excerpt
Programmed death-1 (PD-1) receptor is an inhibitory receptor on hematopoietic cells that can negatively regulate immune responses, particularly responses to tumors, which often upregulate PD-1 ligands. PD-1/PD-1 ligand blocking antibodies can reverse the inhibition and show significant therapeuti...
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