Article
Pro-inflammatory self-reactive T cells are found within murine TCR-αβ(+) CD4(-) CD8(-) PD-1(+) cells.
European journal of immunology - 1 Jun 2016
Rodríguez-Rodríguez Noé, Apostolidis Sokratis A, Fitzgerald Lauren, Meehan Bronwyn S, Corbett Alexandra J, Martín-Villa José Manuel, McCluskey James, Tsokos George C, Crispín José C
Abstract excerpt
TCR-αβ(+) double negative (DN) T cells (CD3(+) TCR-αβ(+) CD4(-) CD8(-) NK1.1(-) CD49b(-) ) represent a minor heterogeneous population in healthy humans and mice. These cells have been ascribed pro-inflammatory and regulatory capacities and are known to expand during the course of several autoimmune diseases. Importantly, previous studies have shown that self-reactive CD8(+) T cells become DN after activation by...
Topics
- Animals
- Autoantigens
- Autoimmunity
- Biomarkers
- CD4 Antigens
- CD8 Antigens
- Cells, Cultured
- Cytokines
- Gene Expression
- Immunophenotyping
- Inflammation
- Inflammation Mediators
- Lymphocyte Activation