Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunoregulatory CD4-CD8- T cells as a potential therapeutic tool for transplantation, autoimmunity, and cancer

1 Jan 2013

Abstract excerpt

A central objective in organ transplantation and the treatment or prevention of autoimmune disease is the achievement of antigen-specific immune tolerance. An additional challenge in bone marrow transplantation for the treatment of hematological malignancies is the prevention of graft-vs-host disease (GVHD) while maintaining graft-vs-tumor activity. Interestingly, CD4(-)CD8(-) (double negative, DN) T cells, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23355840
DOI: 10.3389/fimmu.2013.00006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunoregulatory CD4-CD8- T cells as a potential therapeutic tool for transplantation, autoimmunity, and cancerPMID 23355840Read ↗

Double negative regulatory T cells in transplantation and autoimmunity: recent progress and future directions.Semantic proximity Read ↗

New insights into T cell biology and T cell‐directed therapy for autoimmunity, inflammation, and immunosuppressionSemantic proximity Read ↗

Double‐negative T cells: Setting the stage for disease control or progressionSemantic proximity Read ↗

A comprehensive review of the phenotype and function of antigen-specific immunoregulatory double negative T cells.Semantic proximity Read ↗

Autoimmunity and Cancer—Two Sides of the Same CoinSemantic proximity Read ↗

Memory T cellsSemantic proximity Read ↗

Double-negative T cells: a promising avenue of adoptive cell therapy in transplant oncologySemantic proximity Read ↗

Advances in hematopoietic stem cell transplantation for autoimmune diseasesSemantic proximity Read ↗

Inflammatory CD4/CD8 double-positive human T cells arise from reactive CD8 T cells and are sufficient to mediate GVHD pathologySemantic proximity Read ↗

Tissue‐Resident Memory CD8+ T Cells: Differentiation, Phenotypic Heterogeneity, Biological Function, Disease, and TherapySemantic proximity Read ↗

CD8+ regulatory T cells in solid organ transplantationSemantic proximity Read ↗

A brief history of CD8 T cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.