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Intratumoral heterogeneity of oncogenic drivers in mixed histology lung adenocarcinomas: How tissue selection impacts molecular testing?

Pathology, research and practice - 1 Nov 2024

Krishnamurthy Kritika, Chai Jiani, Liu Xiaowei, Elsayad Mahmoud, Goldstein Doctor Y

Abstract excerpt

Majority of the lung adenocarcinomas show a mixture of different histological patterns. The possibility of histologically heterogeneous areas of the adenocarcinoma showing genetic heterogeneity and harboring different driver mutations, with potentially significant clinical impact, has not been adequately addressed. Currently, there are no guidelines to suggest how to submit tumor tissue in adenocarcinomas with...

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PMID: 39265501
DOI: 10.1016/j.prp.2024.155577

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