Article
MED12 protein expression in breast fibroepithelial lesions: correlation with mutation status and oestrogen receptor expression.
Journal of clinical pathology - 1 Oct 2016
Tan Wai Jin, Chan Jason Yongsheng, Thike Aye Aye, Lim Jeffrey Chun Tatt, Md Nasir Nur Diyana, Tan Jane Sie Yong, Koh Valerie Cui Yun, Lim Weng Khong, Tan Jing, Ng Cedric Chuan Yong, Rajasegaran Vikneswari, Nagarajan Sanjanaa, Bay Boon Huat, Teh Bin Tean, Tan Puay Hoon
Abstract excerpt
AIMS: Recent reports have identified recurrent MED12 somatic mutations in fibroadenomas and phyllodes tumours. The frequency and type of somatic mutations were noted to be similar to those of uterine leiomyomas. We aimed to investigate protein expression of MED12, correlating it to MED12 mutational status and expression of oestrogen receptors (ER). METHODS: Immunohistochemistry was performed on a total of 232...
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