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Article

P2Y12 Receptor Modulates Sepsis-Induced Inflammation.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2016

Liverani Elisabetta, Rico Mario C, Tsygankov Alexander Y, Kilpatrick Laurie E, Kunapuli Satya P

Abstract excerpt

OBJECTIVE: Platelets modulate hemostasis and immune responses via interactions with immune cells through secretion of immunemodulators and cell-cell interactions. The P2Y12 receptor mediates ADP-induced aggregation and secretion in platelets. APPROACH AND RESULTS: Using a mouse model of intra-abdominal sepsis and acute lung injury, we investigated the role of the P2Y12 receptor in neutrophil migration and lung...

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Source

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Identifiers

PMID: 27055904
DOI: 10.1161/ATVBAHA.116.307401
PMCID: PMC4850113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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