Article
P2Y6 receptor potentiates pro-inflammatory responses in macrophages and exhibits differential roles in atherosclerotic lesion development.
PloS one - 1 Jan 2014
Garcia Ricardo A, Yan Mujing, Search Debra, Zhang Rongan, Carson Nancy L, Ryan Carol S, Smith-Monroy Constance, Zheng Joanna, Chen Jian, Kong Yan, Tang Huaping, Hellings Samuel E, Wardwell-Swanson Judith, Dinchuk Joseph E, Psaltis George C, Gordon David A, Glunz Peter W, Gargalovic Peter S
Abstract excerpt
BACKGROUND: P2Y(6), a purinergic receptor for UDP, is enriched in atherosclerotic lesions and is implicated in pro-inflammatory responses of key vascular cell types and macrophages. Evidence for its involvement in atherogenesis, however, has been lacking. Here we use cell-based studies and three murine models of atherogenesis to evaluate the impact of P2Y(6) deficiency on atherosclerosis. METHODOLOGY/PRINCIPAL...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.