Article
Targeting the mRNA-binding protein HuR impairs malignant characteristics of pancreatic ductal adenocarcinoma cells.
Oncotarget - 29 Sept 2015
Jimbo Masaya, Blanco Fernando F, Huang Yu-Hung, Telonis Aristeidis G, Screnci Brad A, Cosma Gabriela L, Alexeev Vitali, Gonye Gregory E, Yeo Charles J, Sawicki Janet A, Winter Jordan M, Brody Jonathan R
Abstract excerpt
Post-transcriptional regulation is a powerful mediator of gene expression, and can rapidly alter the expression of numerous transcripts involved in tumorigenesis. We have previously shown that the mRNA-binding protein HuR (ELAVL1) is elevated in human pancreatic ductal adenocarcinoma (PDA) specimens compared to normal pancreatic tissues, and its cytoplasmic localization is associated with increased tumor stage....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.