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Article

CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype.

Molecular cancer research : MCR - 1 Jun 2017

Lal Shruti, Cheung Edwin C, Zarei Mahsa, Preet Ranjan, Chand Saswati N, Mambelli-Lisboa Nicole C, Romeo Carmella, Stout Matthew C, Londin Eric, Goetz Austin, Lowder Cinthya Y, Nevler Avinoam, Yeo Charles J, Campbell Paul M, Winter Jordan M, Dixon Dan A, Brody Jonathan R

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer-related deaths in the United States, whereas colorectal cancer is the third most common cancer. The RNA-binding protein HuR (ELAVL1) supports a pro-oncogenic network in gastrointestinal (GI) cancer cells through enhanced HuR expression. Using a publically available database, HuR expression levels were determined to be increased in primary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28242812
DOI: 10.1158/1541-7786.MCR-16-0361
PMCID: PMC5466444

Genes

MIA
ELAVL1
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype.PMID 28242812Read ↗

Targeting the mRNA-binding protein HuR impairs malignant characteristics of pancreatic ductal adenocarcinoma cells.Semantic proximity Read ↗

CRISPR/Cas9-Mediated Knockout of the HuR Gene in U251 Cell Inhibits Japanese Encephalitis Virus ReplicationSemantic proximity Read ↗

The RNA-Binding Protein HuR Posttranscriptionally Regulates the Protumorigenic Activator YAP1 in Pancreatic Ductal AdenocarcinomaSemantic proximity Read ↗

Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP InhibitorsSemantic proximity Read ↗

Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells.Semantic proximity Read ↗

Decoding the Complexity of Hepatocellular Carcinoma: Clinical Challenges and Targeting HuR as a Novel Therapeutic StrategySemantic proximity Read ↗

HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer CellsSemantic proximity Read ↗

Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancerSemantic proximity Read ↗

Reduced expression of the RNA-binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27Kip1 levels and poor prognosis.Semantic proximity Read ↗

A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment.Semantic proximity Read ↗

Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer.Semantic proximity Read ↗

miR-29b, miR-205 and miR-221 Enhance Chemosensitivity to Gemcitabine in HuH28 Human Cholangiocarcinoma CellsSemantic proximity Read ↗

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