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Negative control of TRAIL-R1 signaling by transforming growth factor β1 in pancreatic tumor cells involves Smad-dependent down regulation of TRAIL-R1.

Cellular signalling - 1 Nov 2016

Radke David I, Ungefroren Hendrik, Helm Ole, Voigt Susann, Alp Gökhan, Braun Hendrik, Hübner Sebastian, Dilchert Janine, Sebens Susanne, Adam Dieter, Kalthoff Holger, Trauzold Anna

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is characterized by both, overexpression of transforming growth factor (TGF)β and resistance of the tumor cells to many apoptosis-inducing stimuli. The latter negatively impacts the outcome of therapeutic efforts and represents one important mechanism which tumor cells utilize to escape the immune surveillance. Since TGFβ acts as a tumor promoter in advanced tumor stages...

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PMID: 27492861
DOI: 10.1016/j.cellsig.2016.07.016

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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