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Article

RNAi targeting of West Nile virus in mosquito midguts promotes virus diversification.

PLoS pathogens - 1 Jul 2009

Brackney Doug E, Beane Jennifer E, Ebel Gregory D

Abstract excerpt

West Nile virus (WNV) exists in nature as a genetically diverse population of competing genomes. This high genetic diversity and concomitant adaptive plasticity has facilitated the rapid adaptation of WNV to North American transmission cycles and contributed to its explosive spread throughout the New World. WNV is maintained in nature in a transmission cycle between mosquitoes and birds, with intrahost genetic...

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PMID: 19578437
DOI: 10.1371/journal.ppat.1000502
PMCID: PMC2698148

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