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MitoCur‐1 induces ferroptosis to reverse vemurafenib resistance in melanoma through inhibition of USP14

20 Nov 2023

Abstract excerpt

Melanoma is an aggressive malignant tumor with a poor prognosis. Vemurafenib (PLX4032, vem) is applied to specifically treat BRAF V600E-mutated melanoma patients. However, prolonged usage of vem makes patients resistant to the drug and finally leads to clinical failure. We previously tested the combination regimen of tubulin inhibitor VERU-111 with vem, as well as USP14 selective inhibitor b-AP15 in combination...

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PMID: 37985430
DOI: 10.1111/pcmr.13150

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