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Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies

19 Jun 2007

Abstract excerpt

Drugs that target DNA topoisomerase II (Top2), including etoposide (VP-16), doxorubicin, and mitoxantrone, are among the most effective anticancer drugs in clinical use. However, Top2-based chemotherapy has been associated with higher incidences of secondary malignancies, notably the development of acute myeloid leukemia in VP-16-treated patients. This association is suggestive of a link between carcinogenesis...

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PMID: 17578914
DOI: 10.1073/pnas.0704002104

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