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Article

Bioactivation of Napabucasin Triggers Reactive Oxygen Species–Mediated Cancer Cell Death

16 Sept 2019

Abstract excerpt

Abstract Purpose: Napabucasin (2-acetylfuro-1,4-naphthoquinone or BBI-608) is a small molecule currently being clinically evaluated in various cancer types. It has mostly been recognized for its ability to inhibit STAT3 signaling. However, based on its chemical structure, we hypothesized that napabucasin is a substrate for intracellular oxidoreductases and therefore may exert its anticancer effect through redox...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 31527169
DOI: 10.1158/1078-0432.ccr-19-0302

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